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Year Number of Results
1982 1
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1994 11
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412 results

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Page 1
The role of SAMHD1 expression and its relation to HIV-2 (Vpx) gene production.
Bakir TM. Bakir TM. Saudi Pharm J. 2018 Sep;26(6):903-908. doi: 10.1016/j.jsps.2018.03.005. Epub 2018 Mar 12. Saudi Pharm J. 2018. PMID: 30202235 Free PMC article. Review.
However, it does not restrict HIV2 replication in myeloid cells due to the presence of viral Vpx protein. Vpx is a virion-associated protein which augments viral infectivity and it only exists in HIV2 and it has been recently shown in Simian Immunodefi …
However, it does not restrict HIV2 replication in myeloid cells due to the presence of viral Vpx protein. Vpx is a viri …
Human immunodeficiency virus type 2 vpx protein augments viral infectivity.
Kappes JC, Conway JA, Lee SW, Shaw GM, Hahn BH. Kappes JC, et al. Virology. 1991 Sep;184(1):197-209. doi: 10.1016/0042-6822(91)90836-z. Virology. 1991. PMID: 1714662
To examine the function of vpx, we constructed a vpx-deficient HIV-2 proviral clone and characterized its in vitro biological properties. ...In addition, vpx-deficient virions were indistinguishable from wild-type HIV-2 in ultrastructure, composition of major …
To examine the function of vpx, we constructed a vpx-deficient HIV-2 proviral clone and characterized its in vitro biological …
Interaction Between Vpx and SAMHD1, Vital for SAMHD1 Inhibition.
Hasanshahi Z, Dehghani B, Hashempour A. Hasanshahi Z, et al. AIDS Res Hum Retroviruses. 2023 Dec 26. doi: 10.1089/AID.2023.0052. Online ahead of print. AIDS Res Hum Retroviruses. 2023. PMID: 38084955
Therefore, this study aimed to study the interaction between two proteins and the properties of Vpx protein for the first time using bioinformatic tools. ...Our findings indicated the difference in interaction sites among different Vpx. However, in all …
Therefore, this study aimed to study the interaction between two proteins and the properties of Vpx protein for the fir …
New insights into an X-traordinary viral protein.
Schaller T, Bauby H, Hué S, Malim MH, Goujon C. Schaller T, et al. Front Microbiol. 2014 Apr 8;5:126. doi: 10.3389/fmicb.2014.00126. eCollection 2014. Front Microbiol. 2014. PMID: 24782834 Free PMC article. Review.
Vpx is a protein encoded by members of the HIV-2/SIVsmm and SIVrcm/SIVmnd-2 lineages of primate lentiviruses, and is packaged into viral particles. ...However, it is becoming evident that Vpx is a multifunctional protein in that SAMHD1 antagonism is li …
Vpx is a protein encoded by members of the HIV-2/SIVsmm and SIVrcm/SIVmnd-2 lineages of primate lentiviruses, and is packaged …
Viral protein X.
Kappes JC. Kappes JC. Curr Top Microbiol Immunol. 1995;193:121-32. doi: 10.1007/978-3-642-78929-8_7. Curr Top Microbiol Immunol. 1995. PMID: 7648872 Review. No abstract available.
Vpx-Independent Lentiviral Transduction and shRNA-Mediated Protein Knock-Down in Monocyte-Derived Dendritic Cells.
Witkowski W, Vermeire J, Landi A, Naessens E, Vanderstraeten H, Nauwynck H, Favoreel H, Verhasselt B. Witkowski W, et al. PLoS One. 2015 Jul 24;10(7):e0133651. doi: 10.1371/journal.pone.0133651. eCollection 2015. PLoS One. 2015. PMID: 26208151 Free PMC article.
To date, efficient lentiviral transduction of DCs or their monocyte derived counterparts (MDDCs) required high multiplicity of infection (MOI) or the exposure to the HIV-2/SIV protein Vpx to degrade viral restriction factor SAM domain and HD domain-containing pro …
To date, efficient lentiviral transduction of DCs or their monocyte derived counterparts (MDDCs) required high multiplicity of infection (MO …
Small but Highly Versatile: The Viral Accessory Protein Vpu.
Volcic M, Wiesmüller L, Kirchhoff F. Volcic M, et al. Annu Rev Virol. 2023 Sep 29;10(1):243-259. doi: 10.1146/annurev-virology-111821-100816. Epub 2023 Jul 5. Annu Rev Virol. 2023. PMID: 37406340 Free article. Review.
Human and simian immunodeficiency viruses (HIVs and SIVs, respectively) encode several small proteins (Vif, Vpr, Nef, Vpu, and Vpx) that are called accessory because they are not generally required for viral replication in cell culture. ...Here, we discuss the diver …
Human and simian immunodeficiency viruses (HIVs and SIVs, respectively) encode several small proteins (Vif, Vpr, Nef, Vpu, and Vpx …
HIV-2 Vpx neutralizes host restriction factor SAMHD1 to promote viral pathogenesis.
Mohamed A, Bakir T, Al-Hawel H, Al-Sharif I, Bakheet R, Kouser L, Murugaiah V, Al-Mozaini M. Mohamed A, et al. Sci Rep. 2021 Oct 25;11(1):20984. doi: 10.1038/s41598-021-00415-2. Sci Rep. 2021. PMID: 34697376 Free PMC article.
It depletes the dNTPs pool for viral cDNA syntheses, thus preventing the viral replication in the cells. The viral accessory protein, Vpx, exists only in SIVmac/HIV-2 particles. Vpx in SIVmac can induce proteosomal degradation of SAMHD1, which then leads to a …
It depletes the dNTPs pool for viral cDNA syntheses, thus preventing the viral replication in the cells. The viral accessory protein, …
Degradation of SAMHD1 by Vpx Is Independent of Uncoating.
Jáuregui P, Logue EC, Schultz ML, Fung S, Landau NR. Jáuregui P, et al. J Virol. 2015 May;89(10):5701-13. doi: 10.1128/JVI.03575-14. Epub 2015 Mar 11. J Virol. 2015. PMID: 25762741 Free PMC article.
Fusion to the cytoplasmic protein muNS rendered the protein resistant to Vpx-mediated degradation, confirming that SAMHD1 is targeted in the nucleus. ...Using an engineered HeLa cell line that expresses a green fluorescent protein (GFP)-SAMHD1 fusion …
Fusion to the cytoplasmic protein muNS rendered the protein resistant to Vpx-mediated degradation, confirming that SAMH …
[The vpx protein of HIV-2].
Goujon C, Darlix JL, Cimarelli A. Goujon C, et al. Virologie (Montrouge). 2009 Oct 1;13(5):259-269. doi: 10.1684/13-5.2011.14690. Virologie (Montrouge). 2009. PMID: 36151619 French.
The molecular mecanism through which Vpx acts are not understood today, but several lines of evidence suggest that Vpx may act through the recruitment of an ubiquitin-ligase complex. Here, we review the historical and latest developments on the Vpx protein …
The molecular mecanism through which Vpx acts are not understood today, but several lines of evidence suggest that Vpx may act …
412 results